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Advanced 3D-Printed Systems and Nanosystems for Drug Delivery and Tissue Engineering explores the intricacies of nanostructures and 3D printed systems in terms of their design as drug delivery or tissue engineering devices, their further evaluations and diverse applications. The book highlights the most recent advances in both nanosystems and 3D-printed systems for both drug delivery and tissue engineering applications. It discusses the convergence of biofabrication with nanotechnology, constructing a directional customizable biomaterial arrangement for promoting tissue regeneration, combined with the potential for controlled bioactive delivery. These discussions provide a new viewpoint for both biomaterials scientists and pharmaceutical scientists. - Shows how nanotechnology and 3D printing are being used to create systems which are intelligent, biomimetic and customizable to the patient - Explores the current generation of nanostructured 3D printed medical devices - Assesses the major challenges of using 3D printed nanosystems for the manufacture of new pharmaceuticals
Herbal Bioactive-Based Drug Delivery Systems: Challenges and Opportunities provides a wide-ranging, in-depth resource for herbal bioactives, including detailed discussion of standardization and regulations. The book first explores specific drug delivery systems such as gastrointestinal, ocular, pulmonary, transdermal, and vaginal and rectal. It then discusses novel applications for nano, cosmetics, nutraceuticals, wound healing and cancer treatment. Finally, there is a section focusing on standardization and regulation which includes an enhancement of properties. This book is an essential resource for pharmacologists, pharmaceutical scientists, material scientists, botanists, and all those interested in natural products and drug delivery systems developments. - Explores standardization, regulation and enhancement issues in herbal bioactives - Discusses novel developments, herbal cosmetics and toxicity/interaction issues - Provides a comprehensive reference on all aspects of herbal bioactives
Modeling and Control of Drug Delivery Systems provides comprehensive coverage of various drug delivery and targeting systems and their state-of-the-art related works, ranging from theory to real-world deployment and future perspectives. Various drug delivery and targeting systems have been developed to minimize drug degradation and adverse effect and increase drug bioavailability. Site-specific drug delivery may be either an active and/or passive process. Improving delivery techniques that minimize toxicity and increase efficacy offer significant potential benefits to patients and open up new markets for pharmaceutical companies. This book will attract many researchers working in DDS field as it provides an essential source of information for pharmaceutical scientists and pharmacologists working in academia as well as in the industry. In addition, it has useful information for pharmaceutical physicians and scientists in many disciplines involved in developing DDS, such as chemical engineering, biomedical engineering, protein engineering, gene therapy. - Presents some of the latest innovations of approaches to DDS from dynamic controlled drug delivery, modeling, system analysis, optimization, control and monitoring - Provides a unique, recent and comprehensive reference on DDS with the focus on cutting-edge technologies and the latest research trends in the area - Covers the most recent works, in particular, the challenging areas related to modeling and control techniques applied to DDS
This book describes the growing clinical and healthcare relevance of nano-therapeutics in treating respiratory diseases. It begins with a brief introduction on the different types of nanoparticles in respiratory disease conditions. It further discusses the current trends in understanding the disease pathology using different in vitro and in vivo models, which are important towards the onsite clinical applications and development of new therapeutics. The book includes exciting topics such as formulation of these nanoparticles, targeting various organelles etc. It also describes the future prospects and challenges in the field. Different chapters are written by researchers actively working in the area of pulmonary diseases. This book is designed to address the requirements of both beginners and specialized scientists involved in pulmonary research. The contents include basic concepts followed by advanced state-of-art monitoring and treatment of diseases. The book is meant for researchers and industry experts in nanotechnology, pharmaceutical sciences and drug design.
Discusses design chemistry, modification, and processing of biomaterials Describes the efficacy of biomaterials at various scales for biological response and drug delivery Demonstrates technological advances from conventional to additive manufacturing Covers future of biofabrication and customized medical devices
The field of nanomedicine has risen quickly due to the increasing number of designer-made nanomaterials. These nanomaterials have the potential to manage diseases and change the way medicine is currently studied. However, the increased practice of using nanomaterials has shed light on how many concepts of nanomedicine and nanotoxicity have been overlooked. Nanotoxicology: Toxicity Evaluation of Nanomedicine Applications addresses the existing gaps between nanomedicine and nanotoxicity. This book also brings together up-to-date knowledge on advances toward safe-by-design nanomaterials and existing toxicity challenges. This book delivers a comprehensive coverage in the field with fundamental understanding, serving as a platform to convey essential concepts of nanotoxicology and how these concepts can be employed to develop advanced nanomaterials for a range of biomedical applications. This book is an effort to answer some of the thoughtful nanotoxicological complications and their auspicious probable solutions with new approaches and careful toxicity assessment. Key Features: Reveals novel nanoscale approaches, toxicity assessment, and biomedical applications Includes importance of nanotoxicity concepts in developing smart nanomaterials Highlights unique contributions and "A to Z" aspects on the state-of-the-art from global leaders Offers a complete package to learn fundamentals with recommendations on nanomaterials toxicity and safe-by-design nanomedicines Nanotoxicology: Toxicity Evaluation of Nanomedicine Applications illuminates the high potential of many innovative nanomaterials, ultimately demonstrating them to be promising substitutes for available therapies that can be effectively used in fighting a myriad of biomedical complications. Further, this book reports legal, ethical, safety, and regulatory issues associated with nanomaterials, which have often been neglected, if not overlooked in literature and limiting clinical translation at nanoscale level. It will equip readers with cutting-edge knowledge of promising developments in nanomedicine and nanotoxicology, along with potential future prospects.
This book covers the most important topics in the field of personalized orthopedics. It starts with the 3D geometry of the bones, focusing on the problem of reverse engineering of the bones. It also shows the application of a 3D geometric model of bone for the design of personalized implants and prostheses. This book covers the application of additive technologies in personalized orthopedics as well as prediction, simulation and optimization in personalized orthopedics. Its content provides the necessary knowledge for the transition from classical to personalized orthopedics. The authors present an original method for reverse bone engineering—the Method of Anatomical Features (MAF). This method is unique as it enables the reconstruction of the original geometry and topology of the bone, even when only data on its part are available. The application of this method is shown on the examples of human long bones, mandible and hip bone reconstruction. This book contains a review of several real cases of personalized implants. It gives several examples of prostheses for the design of which a 3D model of bones was used, as well as other patient data on the basis of which personalized prostheses were designed.
This book discovers what it will take to reindustrialize the previous industrial powerhouses in order to offset the advantages of cheap labor suppliers dominating the industrial sector by exploring the current situation of the production, processing, and manufacturing industries. The Internet of Things (IoT), Big Data, Cyber-Physical Systems (CPS), and Cloud Computing, Cyber Security, Cobotics, Automation, AI, 3D Printing and Additive Manufacturing, SDN, Blockchain technologies are outlined in this unique and comprehensive book, which has true potential for professionals, researchers, policymakers, and book users. New Horizons for Industry 4.0 in Modern Business encompass trends in business and technology globally that may completely alter how manufacturing and production are conducted. What you will discover: Learn about the Industrial Internet of Things and the Industrial Internet. Learn about the technologies that must develop to support Industry 4.0 and what is being done right now to make that happen. In this book, the topic of Industry 4.0 is covered in detail, and it even moves on to concepts of Digital Twins to boost output and create Industrial Internet of Things. With the development of new digital industrial technology, or "Industry 4.0," it is now feasible to collect and analyze data from many machines, resulting in processes that are quicker, more adaptable, and more efficient, producing things of higher quality while spending less money. The manufacturing revolution will boost productivity, alter economics, promote industrial development, and alter workforce demographics, ultimately altering the competitiveness of businesses and areas. Although advanced digital technology is being employed in manufacturing, Industry 4.0 will completely change how things are done. Greater production efficiencies will result, and conventional connections between suppliers, manufacturers, and consumers—as well as between people and machines—will shift. Industry 4.0 is changing the business process. This disruptive technology is radically changing the way businesses/manufacturing is conducted. It will give machines that little bit of intuition with the help of robotics, 3D printing, artificial intelligence, augmented reality, and virtual reality—that will help them do mindless and repetitive jobs without human intervention, allowing humans to focus more on their core competencies.
Nanophytomedicine is a branch of medicine that involves the application of nanomedicine-based systems to phytotherapy and phytopharmacology and the use of phytonanoparticles for biomedical applications. Nanophytomedicine covers recent advances in experimental and theoretical studies on various properties of nanoparticles derived from plant sources. This book assesses the recent advancements and applications of plant-based nanoparticles and also highlights emerging concepts of biomimetics. The book contains 24 chapters encompassing various therapeutic applications of phytochemicals derived from plants, ferns, seaweeds, and so on, mediated through nanotechnology and its allied approaches. A fervent attempt has been made to compile every significant advancement in the field of phytonanomedicine so as to accelerate its momentum in the pharmaceutical sector.
Biopolymers for Biomedical Applications The twenty chapters written by experts in the field of biopolymers and biomedical engineering, provide a complete resource that systematically discusses the most widely used biopolymers and their biomedical applications, and presents all the important research and developments that have occurred in the field. In recent decades, significant progress has been made in polymer science for biomedical applications. The use of biopolymers specifically attracted the focus on the development of therapeutic polymeric systems. The exclusive features of biopolymers, such as biodegradability and biocompatibility make them highly sought after, and major research conducted with them has resulted in various therapeutic systems. However, until now only a few showed a potential to be appropriate for human use. Each chapter covers a single biopolymer, its properties, and biomedical applications. The chapters are arranged systematically, with the most common biopolymers discussed early in the book to give more insight into the field. Further, a specific chapter is dedicated to the application of biopolymers for wound healing. Later, specific chapters are dedicated to the application of bioplastics and biopolymers for the development of medical devices and biosensors, respectively. Additionally, a chapter is dedicated to the application of biopolymers in the field of dentistry, with a special focus on their risk to human health. Keeping in mind recent advanced technologies, a chapter is dedicated solely to the latest progress of biopolymers in 3D and 4D printing for biomedical applications. The final chapter comprehensively explains the future perspectives of biopolymers in the biomedical field. Audience The book is a reference source for scientists, research scholars, chemical and polymer engineers, biologists, biotechnologists, polymer technologists, industrialists, health experts, and policymakers.