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In broad terms, the present day existence of all forms of life on earth is the result of adaptation by organisms over time to the given environment/circumstance. More recently, it has also been seen that a gradual adaptation to repeat exposures to different stresses such as hypoxia, heat, cold, infections, exercise, etc. increases the resistance of the organisms not only to each of these stresses, but also to other potentially harmful conditions. An understanding of the science behind the process of such an adaptation is the key to future therapies. Several chapters in this book cover new developments in our understanding of the biology of adaptation at the molecular, cellular, organ and whole body level. Some of the chapters also consider translational aspects of such a knowledge. This book will be of great value to experimental biologists as well as clinicians who deal with a wide variety of disease conditions.
This title is directed primarily towards health care professionals outside of the United States. It starts with the origin of life and ends with the mechanisms that make muscles adapt to different forms of training. In between, it considers how evidence has been obtained about the extent of genetic influence on human capacities, how muscles and their fibres are studied for general properties and individual differences, and how molecular biological techniques have been combined with physiological ones to produce the new discipline of molecular exercise physiology. This is the first book on such topics written specifically for modules in exercise and sport science at final year Hons BSc and taught MSc levels.
Recognition of adaptive processes in biological systems as a discipline is still in its infancy. It is known that repeat exposure to low level stresses such as heat, cold, microgravity, hypoxia, exercise, etc. increases body-resistance to not only the particular stress but also to other conditions. Such a cross-protection can be utilized in a better patient care. This volume describes most current developments in the understanding of the molecular basis of adaptation as well as its application in biological systems including certain disease conditions in humans. The book is based on the presentations made by internationally known experts assembled in San Diego, USA for the 7th World Congress of the International Society for Adaptive Medicine and will be of great interest to experimental biologists as well as clinicians who deal with a wide variety of clinical conditions.
Recognition of adaptive processes in biological systems as a discipline is still in its infancy. It is known that repeat exposure to low level stresses such as heat, cold, microgravity, hypoxia, exercise, etc. increases body-resistance to not only the particular stress but also to other conditions. Such a cross-protection can be utilized in a better patient care. This volume describes most current developments in the understanding of the molecular basis of adaptation as well as its application in biological systems including certain disease conditions in humans. The book is based on the presentations made by internationally known experts assembled in San Diego, USA for the 7th World Congress of the International Society for Adaptive Medicine and will be of great interest to experimental biologists as well as clinicians who deal with a wide variety of clinical conditions.
Although the entire evolution of life is an adaptation right from the coming-together of the elements and reaching to human life as we know today, the realization of the adaptation biology as a discipline is relatively recent. Furthermore, subcellular basis of gradual adaptation of body systems in stressful conditions is still a greate mystery of biology. The present book attempts to fill that gap. It is known that such an adaptation not only increases tolerance of the body to that given stress but also to other challenges. A complete knowledge of this cross protection needs to be defined and exp;oited to improve patient care. The book includes chapters describing subcellular adaptations; adaptation to different stresses as well as to lifestyle and environment. Although for an easy reading the information has been grouped under the sub-heading: Current Trends, the book represents a common continuum of adaptations. The therapeutic value of the understanding of the science of adaptation has also been described in several chapters. Examples of cross adaptations are also provided, where repeated exposure to one stinulus may ptentialyy be used in the treatment as well as prophylaxis of different diseases.The present book will be of great interest to all biologists, physiologists, pharmacologists and physicians interested in the application of the biology of adaptation in the improvement of health.
It has become amply clear that all live forms on Earth are the products of the constituent genes expressed under the influence of continuously changing natural environment. By the same token, gene expression is known to be modified by our (or by the modern) environment inclusive of factors such as gravity, altitude, temperature, atmospheric pressure and air quality, physical conditioning as well as nutrition and/or lifestyle. Life would not survive without recruiting endogenous adaptive mechanisms responsive to challenging environmnetal factors, Biology of adaptation as well as application of this knowledge has been discussed in both health and disease conditions such as cardiac ischemia and cardiomyopathies, stroke, dementia, Alzheimer's, cancer, metal toxicity, etc. The book will be of great interest to experimental biologists and health professionals dealing with benefits and failures of physiological and pathophysiological adaptations. It will also serve as an important source of information for young scientists, postdocs and students.
Taking a science-based look at an emerging area of medicine, Adaptive Biology and Medicine: New Frontiers, Volume 3 discusses the biology of adaptation at the molecular, cellular, and system levels in response to a variety of stressful conditions. Leading international experts present a total of 37 chapters that cover a common continuum of adaptations. For easy reading, the information has been grouped under the sub-headings: Cardiovasular Adaptation, Adaptations to Changes in Altitude and Microgravity, and Environmental Stresses. Examples of cross adaptations are included where repeated exposure to one stimulus may have applications in the treatment and prophylaxis of different diseases. Understanding disease and the mechanisms involved can help us fight disease. When you look at illness through the lens of adaptive biology you can sometimes see medical problems in a new and thought-provoking light. Offering promise for therapeutic strategies in both experimental and clinical pathology, Adaptive Biology and Medicine: New Frontiers explores a new way of thinking about physiological adaptations and their link to disease development.
Biological evolution is a fact—but the many conflicting theories of evolution remain controversial even today. When Adaptation and Natural Selection was first published in 1966, it struck a powerful blow against those who argued for the concept of group selection—the idea that evolution acts to select entire species rather than individuals. Williams’s famous work in favor of simple Darwinism over group selection has become a classic of science literature, valued for its thorough and convincing argument and its relevance to many fields outside of biology. Now with a new foreword by Richard Dawkins, Adaptation and Natural Selection is an essential text for understanding the nature of scientific debate.
This collection of forty new essays, written by the leading scholars in adaptation studies and distinguished contributors from outside the field, is the most comprehensive volume on adaptation ever published. Written to appeal alike to specialists in adaptation, scholars in allied fields, and general readers, it hearkens back to the foundations of adaptation studies a century and more ago, surveys its ferment of activity over the past twenty years, and looks forward to the future. It considers the very different problems in adapting the classics, from the Bible to Frankenstein to Philip Roth, and the commons, from online mashups and remixes to adult movies. It surveys a dizzying range of adaptations around the world, from Latin American telenovelas to Czech cinema, from Hong Kong comics to Classics Illustrated, from Bollywood to zombies, and explores the ways media as different as radio, opera, popular song, and videogames have handled adaptation. Going still further, it examines the relations between adaptation and such intertextual practices as translation, illustration, prequels, sequels, remakes, intermediality, and transmediality. The volume's contributors consider the similarities and differences between adaptation and history, adaptation and performance, adaptation and revision, and textual and biological adaptation, casting an appreciative but critical eye on the theory and practice of adaptation scholars--and, occasionally, each other. The Oxford Handbook of Adaptation Studies offers specific suggestions for how to read, teach, create, and write about adaptations in order to prepare for a world in which adaptation, already ubiquitous, is likely to become ever more important.
Genetic algorithms are playing an increasingly important role in studies of complex adaptive systems, ranging from adaptive agents in economic theory to the use of machine learning techniques in the design of complex devices such as aircraft turbines and integrated circuits. Adaptation in Natural and Artificial Systems is the book that initiated this field of study, presenting the theoretical foundations and exploring applications. In its most familiar form, adaptation is a biological process, whereby organisms evolve by rearranging genetic material to survive in environments confronting them. In this now classic work, Holland presents a mathematical model that allows for the nonlinearity of such complex interactions. He demonstrates the model's universality by applying it to economics, physiological psychology, game theory, and artificial intelligence and then outlines the way in which this approach modifies the traditional views of mathematical genetics. Initially applying his concepts to simply defined artificial systems with limited numbers of parameters, Holland goes on to explore their use in the study of a wide range of complex, naturally occuring processes, concentrating on systems having multiple factors that interact in nonlinear ways. Along the way he accounts for major effects of coadaptation and coevolution: the emergence of building blocks, or schemata, that are recombined and passed on to succeeding generations to provide, innovations and improvements.