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Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Basics of Cryosurgery is the first publication specialising in the fundamentals of modern cryosurgery. This book presents what is currently known in modern cryosurgery and is the first on the subject to appear at the start of the third millennium. It aims to contribute to the further development of this branch of medicine, which is set to become indispensable in treating patients. Basics of Cryosurgery is a unique contribution - no previous work has compiled in one source all available scientific data on the theoretical, experimental, and clinical investigations that have been undertaken in the field of cryosurgery.
This atlas presents the fundamental aspects of modern cryosurgery. In the case of cancer patients it shows the discipline's advantages when compared to conventional surgical approaches. The text features definitions of the most frequently used terms, short descriptions of the historical and scientific background of cryosurgery, and an outline of cryosurgical equipment and techniques. Still further, the text covers the whole spectrum of experimental and clinical cryosurgery and the results of cryosurgical treatment of tumours in, for example, the liver, lung, and brain. Over 500 illustrations, mostly in colour, demonstrate the cryosurgical approach.
Introducing the most recent advances in crystallography, nuclear magnetic resonance, molecular modeling techniques, and computational combinatorial chemistry, this unique, interdisciplinary reference explains the application of three-dimensional structural information in the design of pharmaceutical drugs. Furnishing authoritative analyses by world-renowned experts, Structure-Based Drug Design discusses protein structure-based design in optimizing HIV protease inhibitors and details the biochemical, genetic, and clinical data on HIV-1 reverse transcriptase presents recent results on the high-resolution three-dimensional structure of the catalytic core domain of HIV-1 integrase as a foundation for divergent combination therapy focuses on structure-based design strategies for uncovering receptor antagonists to treat inflammatory diseases demonstrates a systematic approach to the design of inhibitory compounds in cancer treatment reviews current knowledge on the Interleukin-1 (IL-1) system and progress in the development of IL-1 modulators describes the influence of structure-based methods in designing capsid-binding inhibitors for relief of the common cold and much more!
Cryosurgery is a surgical technique that employs freezing to destroy undesirable tissue. From as early as 3500 BC, there is evidence for the use of cold in medicine for the treatment of infected wounds of the chest, fracture of the skull and various injuries. However, the history of “modern” cryosurgery is relatively short and is closely intertwined with the development in low temperature physics, engineering, and instrumentation during the last century.From the early 21st century, advanced helium-based cryosurgery has been applied worldwide. More than ten thousand patients with malignant and benign tumors have received cryosurgery. It is specially noted that in most cases cryosurgery, as a mini-invasive ablation technique, was performed with percutaneous approach under guidance of CT or ultrasound. Cryosurgery is now one of the more popular techniques in China, with nearly 6000 cases of tumors receiving cryosurgery in the author's institution alone. This book summarizes the experimental and clinical experience and practice of cryosurgery, and describes the basics of cryosurgery and its use in the treatment of various tumors.
Annotation The three volume set LNAI 5177, LNAI 5178, and LNAI 5179, constitutes the refereed proceedings of the 12th International Conference on Knowledge-Based Intelligent Information and Engineering Systems, KES 2008, held in Zagreb, Croatia, in September 2008. The 316 revised papers presented were carefully reviewed and selected. The papers present a wealth of original research results from the field of intelligent information processing in the broadest sense; topics covered in the first volume are artificial neural networks and connectionists systems; fuzzy and neuro-fuzzy systems; evolutionary computation; machine learning and classical AI; agent systems; knowledge based and expert systems; intelligent vision and image processing; knowledge management, ontologies, and data mining; Web intelligence, text and multimedia mining and retrieval; and intelligent robotics and control.