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Yeast Genetics: Methods and Protocols is a collection of methods to best study and manipulate Saccharomyces cerevisiae, a truly genetic powerhouse. The simple nature of a single cell eukaryotic organism, the relative ease of manipulating its genome and the ability to interchangeably exist in both haploid and diploid states have always made it an attractive model organism. Genes can be deleted, mutated, engineered and tagged at will. Saccharomyces cerevisiae has played a major role in the elucidation of multiple conserved cellular processes including MAP kinase signaling, splicing, transcription and many others. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Yeast Genetics: Methods and Protocols will provide a balanced blend of classic and more modern genetic methods relevant to a wide range of research areas and should be widely used as a reference in yeast labs.
This two-volume book presents the outcomes of the 8th International Conference on Soft Computing for Problem Solving, SocProS 2018. This conference was a joint technical collaboration between the Soft Computing Research Society, Liverpool Hope University (UK), and Vellore Institute of Technology (India), and brought together researchers, engineers and practitioners to discuss thought-provoking developments and challenges in order to select potential future directions. The book highlights the latest advances and innovations in the interdisciplinary areas of soft computing, including original research papers on algorithms (artificial immune systems, artificial neural networks, genetic algorithms, genetic programming, and particle swarm optimization) and applications (control systems, data mining and clustering, finance, weather forecasting, game theory, business and forecasting applications). It offers a valuable resource for both young and experienced researchers dealing with complex and intricate real-world problems that are difficult to solve using traditional methods.
The landmark pediatrics reference -- now extensively updated in full color and more clinically relevant than ever A Doody's Core Title ESSENTIAL PURCHASE for 2011! Rudolph's Pediatrics has virtually defined the pediatric field for over a century, becoming one of the most important and well-respected pediatrics texts ever published. Renowned for its balance of clinical features and treatment of disease with underlying biological principles, this classic sourcebook has helped generations of pediatricians optimize their care of infants, children, and adolescents. The 22nd edition of Rudolph's Pediatrics continues a long tradition of adapting its content to changes in our understanding of children's health and disease, providing an up-to-date, in-depth survey of pediatric medicine unmatched by any other text. With its algorithmic approach to pediatric systems, the book facilitates the diagnosis and treatment of both common and uncommon pediatric illnesses; and it reflects new technologies and advances in molecular medicine that continue to evolve with current thinking about normal childhood development and pediatric disease processes. NEW TO THIS EDITION: New four-color design adds depth and clarity to the book's content Over 900 full-color, high-quality images and illustrations A reorganized, reader-friendly format broken down into sections and chapters for easier navigation and reference New emphasis on the clinical management of the patient makes this the most practical edition to date New sections provide a timely overview of pediatric care fundamentals and an entirely revised discussion of health promotion and disease prevention Substantially revised sections cover key areas of pediatric study and practice, including infectious diseases, immunology, allergy, neoplastic disorders, the cardiovascular system, urinary complications, and more Greater use of tables and lists conveniently summarize need-to-know diagnostic and therapeutic information New DVD of additional content featuring over 1700 figures, 1100 tables, and 30,000 references
Diterpenoids are chemical compounds containing 20 carbon atoms and belong to the terpenoid class. They derive from geranylgeraniol, a C20 precursor, have a C20H32 basic structure, and are composed of four isoprene units. These features make diterpenoids different from simple terpenes, which possess only 10 carbon atoms. A diterpenoid molecule may also include alcohol, phenol, aldehyde, cheton, or acidic functional groups. These compounds are highly lipophilic, odorless, and may possess strong flavours. They are found mainly in fungi and in resins of higher-order plants, as typical products of plant metabolism. This book examines the types, functions and provides new research on diterpenoids.
Rationality problems link algebra to geometry, and the difficulties involved depend on the transcendence degree of $K$ over $k$, or geometrically, on the dimension of the variety. A major success in 19th century algebraic geometry was a complete solution of the rationality problem in dimensions one and two over algebraically closed ground fields of characteristic zero. Such advances has led to many interdisciplinary applications to algebraic geometry. This comprehensive book consists of surveys of research papers by leading specialists in the field and gives indications for future research in rationality problems. Topics discussed include the rationality of quotient spaces, cohomological invariants of quasi-simple Lie type groups, rationality of the moduli space of curves, and rational points on algebraic varieties. This volume is intended for researchers, mathematicians, and graduate students interested in algebraic geometry, and specifically in rationality problems. Contributors: F. Bogomolov; T. Petrov; Y. Tschinkel; Ch. Böhning; G. Catanese; I. Cheltsov; J. Park; N. Hoffmann; S. J. Hu; M. C. Kang; L. Katzarkov; Y. Prokhorov; A. Pukhlikov
Across the borderlands of the early American northeast, New England, New France, and Native nations deployed women with surprising frequency to the front lines of wars that determined control of North America. Far from serving as passive helpmates in a private, domestic sphere, women assumed wartime roles as essential public actors, wielding muskets, hatchets, and makeshift weapons while fighting for their families, communities, and nations. Revealing the fundamental importance of martial womanhood in this era, Gina M. Martino places borderlands women in a broad context of empire, cultural exchange, violence, and nation building, demonstrating how women's war making was embedded in national and imperial strategies of expansion and resistance. As Martino shows, women's participation in warfare was not considered transgressive; rather it was integral to traditional gender ideologies of the period, supporting rather than subverting established systems of gender difference. In returning these forgotten women to the history of the northeastern borderlands, this study challenges scholars to reconsider the flexibility of gender roles and reveals how women's participation in transatlantic systems of warfare shaped institutions, polities, and ideologies in the early modern period and the centuries that followed.
How does an illiterate singer produce a long oral epic? What is the origin of his "text", available only for a fleeting moment at its performance? How can a multifaceted oral performance be transformed into a book? The primary oral textualization and the secondary written codification of the Siri epic, 15,683 lines, are described in detail in the present volume on the basis of recent fieldwork among the speakers of Tulu, a Dravidian language, in southern Karnataka, India. The "oral author", Mr Gopala Naika, is one of the many talented singers of oral epics in Tulunaadu and a possession priest in rituals which use oral epics as their mythical charter and a source of mental therapy.