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Tentative estimates of the sharp-rising overpressures as a function of duration which represent a lethal hazard to the 70-kg animal 1, 50 and 99 per cent of the time were presented. The predictions were based on interspecies correlations and extrapolations encompassing blast-tolerance data for six mammalian species. The tentative application of the data to indicate human blast tolerance was discussed and relevant uncertainties in the estimates were emphasized. It was also pointed out that biologic tolerance would be different for air-blast pulses having non-ideal wave forms frequently associated with various geometries of exposure. Selected pathophysiological information pertinent to the biological response following blast exposure was given; namely survival time and selected postshot observations of dogs and goats.