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The use of aromatic plants has been practised since ancient times as is evidenced by records of Chinese, Egyptian, Mesopotamian, Greek and Roman origin; recent findings in Pakistan prove that it goes as far back as 5000 years. Accordingly, the importance and value ascribed to them were always high. Either as a medicine, a foodstuff, a seasoning, a cosmetic or an element of religious rituals the aromatic plant was indispensable. It is not to be forgotten that desire tor the riches of India - spices among which - and the struggle to monopolize the trade of the latter con tributed to the opening of new sea routes, discovering of continents and altering the picture of the known world. With the advent of modern civilization, characterized by scientific and technological development which dIverted estimation and consumption towards artificial products, aromatic plants experienced a temporary de cline of use retaining, however, theIr importance In sectors such as the culinary art and cosmetics industry.
Medicinal chemists around the world have been inspired by nature and have successfully extracted chemicals from plants. Research on enzymatic modifications of naturally occurring compounds has played a critical role in the search for biologically active molecules to treat diseases. This book explores compounds of interest to researchers and clinicians. It presents a comprehensive analysis about the medicinal chemistry (drug design, structure-activity relationships, permeability data, cytotoxicity, appropriate statistical procedures, molecular modelling studies) of different compounds. Each chapter brings contributions from known scientists explaining experimental results which can be translated into clinical practice. Each chapter follows a specific format for a phytochemical agent with common chemical features: • General background on the (phyto)chemistry of the scaffold • General background on the pharmacological profile of the scaffold • A Description of the proposed derivatives and their advantages with respect to the parent compounds (emphasizing the synthetic approaches and structure-activity relationships) • In silico analysis of the crucial interactions with the biological target • Clinical studies and patent survey (if available) on the new and proposed structures The objective of this book set is to fulfil gaps in currently acquired knowledge with information from the recent years. It serves as a guide for academic and professional researchers and clinicians.
This volume provides a contemporary overview of new strategies for traditional medicine development. It emphasizes the importance of cataloging ethnomedical information, determining the active principles, and examining the genetic diversity and range of actions of traditional medicines. It discusses the challenges of using traditional medicines for diseases where access to modern medicine is limited, and the research areas needed to improve quality, safety, and efficacy for enhancing healthcare. Affirming the importance of traditional medicines as an essential and integral component of healthcare systems, it explores the vast opportunities for their evidence-based development.
Kew Record of Taxonomic Literature Relating to Vascular Plants