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Reprint of the original, first published in 1876.
Healthcare providers, consumers, researchers and policy makers are inundated with unmanageable amounts of information, including evidence from healthcare research. It has become impossible for all to have the time and resources to find, appraise and interpret this evidence and incorporate it into healthcare decisions. Cochrane Reviews respond to this challenge by identifying, appraising and synthesizing research-based evidence and presenting it in a standardized format, published in The Cochrane Library (www.thecochranelibrary.com). The Cochrane Handbook for Systematic Reviews of Interventions contains methodological guidance for the preparation and maintenance of Cochrane intervention reviews. Written in a clear and accessible format, it is the essential manual for all those preparing, maintaining and reading Cochrane reviews. Many of the principles and methods described here are appropriate for systematic reviews applied to other types of research and to systematic reviews of interventions undertaken by others. It is hoped therefore that this book will be invaluable to all those who want to understand the role of systematic reviews, critically appraise published reviews or perform reviews themselves.
This handbook is volume II in a series collecting mathematical state-of-the-art surveys in the field of dynamical systems. Much of this field has developed from interactions with other areas of science, and this volume shows how concepts of dynamical systems further the understanding of mathematical issues that arise in applications. Although modeling issues are addressed, the central theme is the mathematically rigorous investigation of the resulting differential equations and their dynamic behavior. However, the authors and editors have made an effort to ensure readability on a non-technical level for mathematicians from other fields and for other scientists and engineers. The eighteen surveys collected here do not aspire to encyclopedic completeness, but present selected paradigms. The surveys are grouped into those emphasizing finite-dimensional methods, numerics, topological methods, and partial differential equations. Application areas include the dynamics of neural networks, fluid flows, nonlinear optics, and many others.While the survey articles can be read independently, they deeply share recurrent themes from dynamical systems. Attractors, bifurcations, center manifolds, dimension reduction, ergodicity, homoclinicity, hyperbolicity, invariant and inertial manifolds, normal forms, recurrence, shift dynamics, stability, to namejust a few, are ubiquitous dynamical concepts throughout the articles.
Handbook of Modern Pharmaceutical Analysis, Second Edition, synthesizes the complex research and recent changes in the field, while covering the techniques and technology required for today's laboratories. The work integrates strategy, case studies, methodologies, and implications of new regulatory structures, providing complete coverage of quality assurance from the point of discovery to the point of use. - Treats pharmaceutical analysis (PA) as an integral partner to the drug development process rather than as a service to it - Covers method development, validation, selection, testing, modeling, and simulation studies combined with advanced exploration of assays, impurity testing, biomolecules, and chiral separations - Features detailed coverage of QA, ethics, and regulatory guidance (quality by design, good manufacturing practice), as well as high-tech methodologies and technologies from "lab-on-a-chip" to LC-MS, LC-NMR, and LC-NMR-MS