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Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms presents the role of ROS?mediated pathways cellular signaling stress, endoplasmic reticulum (ER) stress, oxidative stress, oxidative damage, nanomaterials, and the mechanisms by which metalloids and nanoparticles induce their toxic effects. The book covers the ecotoxicology of environmental heavy metal ions and free radicals on macromolecules cells organisms, heavy metals?induced cell responses, oxidative stress, the source of oxidants, and the roles of ROS, oxidative stress and oxidative damage mechanisms. It also examines the nanotoxicity, cytotoxicity and genotoxicity mechanisms of nanomaterials and the effects of nanoparticle interactions. Antioxidant defense therapy and strategies for treatment round out the book, making it an ideal resource for researchers and professional scientists in toxicology, environmental chemistry, environmental science, nanomaterials and the pharmaceutical sciences. - Covers the ecotoxicology of environmental heavy metal ions and the interactions between specific heavy metals?induced cell responses and oxidative stress - Provides a better understanding of the mechanism of nanomaterial-induced toxicity as a first defense for hazard prevention - Covers recent advances in new nanomedication technologies for the effects of NPs on oxidative stress, ROS and ER stress - Discusses the effects of interactions between antioxidant defense therapy, ROS and strategies for treatment
Aging has long since been ascribed to the gradual accumulation of DNA mutations in the genome of somatic cells. However, it is only recently that the necessary sophisticated technology has been developed to begin testing this theory and its consequences. Vijg critically reviews the concept of genomic instability as a possible universal cause of aging in the context of a new, holistic understanding of genome functioning in complex organisms resulting from recent advances in functional genomics and systems biology. It provides an up-to-date synthesis of current research, as well as a look ahead to the design of strategies to retard or reverse the deleterious effects of aging. This is particularly important in a time when we are urgently trying to unravel the genetic component of aging-related diseases. Moreover, there is a growing public recognition of the imperative of understanding more about the underlying biology of aging, driven by continuing demographic change.
This book highlights the latest advances made in the niche area of Reactive Oxygen Species and Redox processes in plants. It offers a valuable guide for researchers and students alike, providing insights into sensing, detox scavenging, the role in oxidative deterioration, and signaling associated with redox-regulatory processes in plants. The book also dramatically demonstrates how these amazingly resourceful molecular species and radicals are poised at the core of a sophisticated network of signaling pathways, and act as vital regulators of plants’ cell physiology and cellular responses to the environment. The molecular language associated with ROS-mediated signal transduction, which produces modulations in gene expression that determine plants’ stress acclamatory performance, is also discussed. The book subsequently provides information on current trends in redox proteomics and genomics, which include efforts to gain a fuller understanding of these redox players’ role in cellular processes, and to further the application of this knowledge to technology and agriculture. Given its scope and format, the book offers a valuable asset for students of Plant Sciences, Agriculture, and Molecular Biology, as well as readers engaged in research on and teaching ROS Biology.
Biology of Stress in Fish: Fish Physiology provides a general understanding on the topic of stress biology, including most of the recent advances in the field. The book starts with a general discussion of stress, providing answers to issues such as its definition, the nature of the physiological stress response, and the factors that affect the stress response. It also considers the biotic and abiotic factors that cause variation in the stress response, how the stress response is generated and controlled, its effect on physiological and organismic function and performance, and applied assessment of stress, animal welfare, and stress as related to model species. - Provides the definitive reference on stress in fish as written by world-renowned experts in the field - Includes the most recent advances and up-to-date thinking about the causes of stress in fish, their implications, and how to minimize the negative effects - Considers the biotic and abiotic factors that cause variation in the stress response
This book describes the methods of analysis and determination of oxidants and oxidative stress in biological systems. Reviews and protocols on select methods of analysis of ROS, RNS, oxygen, redox status, and oxidative stress in biological systems are described in detail. It is an essential resource for both novices and experts in the field of oxidant and oxidative stress biology.
Oxygen represents only 20% of the Earth's atmosphere, yet it is vital for the survival of aerobic organisms. There is a dark part of the use of oxygen that consists in generating reactive species that are potentially harmful to living organisms. Moreover, reactive oxygen species can combine with nitrogen derivatives and generate many other reactive species. Thus, living organisms are continuously assaulted by reactive species from external or internal sources. However, the real danger comes in the case of high concentrations and prolonged exposure to these species. This book presents an image of the mechanisms of action of reactive species and emphasizes their involvement in diseases. Inflammation and cancer are examined to determine when and how reactive species turn the evolution of a benign process to a malignant one. Some answers may come from recent studies indicating that reactive species are responsible for epigenetic changes.
Describes the basics of ROS metabolism in plants and examines the broad range of ROS signaling mechanisms New discoveries about the effects of reactive oxygen species (ROS) on plants have turned ROS from being considered a bane into a boon, because their roles have been discovered in many plant developmental processes as signaling molecules. This comprehensive book teaches about the role of ROS metabolism in plants and how they affect various developmental processes. It also discusses in detail the advancements made in understanding the ROS signaling. Reactive Oxygen Species in Plants: Boon Or Bane - Revisiting the Role of ROS begins by presenting the basic introduction to ROS and deciphers the detailed knowledge in ROS research. It then examines the broad range of ROS signaling mechanisms as well as how they may be beneficial for plants and human beings. This book also describes both the bane and boon aspects of ROS with their impact on plants, and how the recent revelations have compelled us to rethink ROS turning from stressors to plant regulators. ● Compiles, for the first time, the wholesome knowledge in ROS research and their cellular signaling ● Includes new discoveries and in-depth discussions about the advancements made in the field ● Discusses reactive oxygen species which are involved in a broad range of biological processes Reactive Oxygen Species in Plants: Boon Or Bane - Revisiting the Role of ROS will help scientists to utilize the functions of ROS signaling for plants and also enable readers to gain a deeper knowledge of ROS research and signaling. It is highly recommended for researchers, scientists, and academicians in plant science as well for advanced undergraduate and postgraduate students.
DNA Sensors and Inflammasomes, Volume 625, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. New sections in this release include Phosphorylation and dimerization of STING and IRF3, cGAS enzymology, Synthesis and identification of immuno-stimulatory CDNs, Tracking cGAS activity/ cGAMP formation using SPR/NMR, Using an enzyme coupled assay to track cGAS activity under steady states, Tracking the polymerization of DNA sensors, inflammasome receptors, and downstream signaling partners using FRET, NLRC4 structure, Tracking TREX1 activity, DNA association and dissociation kinetics of PARP1, and more.
The focus of this collection of illustrated reviews is to discuss the systems biology of free radicals and anti-oxidants. Free radical induced cellular damage in a variety of tissues and organs is reviewed, with detailed discussion of molecular and cellular mechanisms. The collection is aimed at those new to the field, as well as clinicians and scientists with long standing interests in free radical biology. A feature of this collection is that the material also brings insights into various diseases where free radicals are thought to play a role. There is extensive discussion of the success and limitations of the use of antioxidants in several clinical settings.
Presents a multidisciplinary analysis of the integration among reactive oxygen species (ROS), reactive nitrogen species (RNS), and reactive sulfur species (RSS). Since plants are the main source of our food, the improvement of their productivity is the most important task for plant biologists. In this book, leading experts accumulate the recent development in the research on oxidative stress and approaches to enhance antioxidant defense system in crop plants. They discuss both the plant responses to oxidative stress and mechanisms of abiotic stress tolerance, and cover all of the recent approaches towards understanding oxidative stress in plants, providing comprehensive information about the topics. It also discusses how reactive nitrogen species and reactive sulfur species regulate plant physiology and plant tolerance to environmental stresses. Reactive Oxygen, Nitrogen and Sulfur Species in Plants: Production, Metabolism, Signaling and Defense Mechanisms covers everything readers need to know in four comprehensive sections. It starts by looking at reactive oxygen species metabolism and antioxidant defense. Next, it covers reactive nitrogen species metabolism and signaling before going on to reactive sulfur species metabolism and signaling. The book finishes with a section that looks at crosstalk among reactive oxygen, nitrogen, and sulfur species based on current research done by experts. Presents the newest method for understanding oxidative stress in plants. Covers both the plant responses to oxidative stress and mechanisms of abiotic stress tolerance Details the integration among reactive oxygen species (ROS), reactive nitrogen species (RNS) and reactive sulfur species (RSS) Written by 140 experts in the field of plant stress physiology, crop improvement, and genetic engineering Providing a comprehensive collection of up-to-date knowledge spanning from biosynthesis and metabolism to signaling pathways implicated in the involvement of RONSS to plant defense mechanisms, Reactive Oxygen, Nitrogen and Sulfur Species in Plants: Production, Metabolism, Signaling and Defense Mechanisms is an excellent book for plant breeders, molecular biologists, and plant physiologists, as well as a guide for students in the field of Plant Science.