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A Primer of Human Genetics is an introductory textbook designed to give students the foundation they need to understand and appreciate the extraordinary shifts in human genetics that have accompanied the arrival of genomics. The book lays out the key concepts of human evolution, quantitative genetics, and personalized medicine before describing the tools that are missing from most contemporary textbooks: genome-wide association studies, whole-genome resequencing, gene expression and epigenome profiling, and integrative genomics. The final section provides an up-to-date survey of specific findings in six major domains of human disease: immunological, metabolic, cardiovascular, cancer, neuropsychological, and aging disorders. After reading this textbook, not only will students be better equipped to read current literature, they will gain a sense of the impact that the revolution in genomics has had for our understanding of the human condition, as well as of the major trends in human genetics research. Students are assumed to have a core understanding of genetics such as would be obtained in a general genetics class. Each chapter is approximately 20 pages long, and organized under up to ten sub-headings, most of which incorporate an illustrative figure. Chapter summary points recap the key messages, and references point students to key reviews and contemporary highlights. Several of the chapters contain a single box, which provides extra material on topics such as 'Consent and Responsible Conduct of Research' and 'Methylation Analysis in Biology.'
An invaluable student-tested study aid, this primer, first published in 2007, provides guided instruction for the analysis and interpretation of genetic principles and practice in problem solving. Each section is introduced with a summary of useful hints for problem solving and an overview of the topic with key terms. A series of problems, generally progressing from simple to more complex, then allows students to test their understanding of the material. Each question and answer is accompanied by detailed explanation. This third edition includes additional problems in basic areas that often challenge students, extended coverage in molecular biology and development, an expanded glossary of terms, and updated historical landmarks. Students at all levels, from beginning biologists and premedical students to graduates seeking a review of basic genetics, will find this book a valuable aid. It will complement the formal presentation in any genetics textbook or stand alone as a self-paced review manual.
Basic Genetics is a concise introductory textbook that focuses not only on understanding and explaining the main points of genetics, but also upon covering the required essential traditional subjects in the field. The main goal of this textbook is to help first year students who are taking their first course in human genetics to understand the different topics within genetics. It is of particular interest for those who are preparing themselves to study medicine or other medical sciences. This textbook presents only the essential required information. Some of the different subjects included in the eight chapters are: cell cycle and cellular division, Mendelian principles of heredity, the molecular basis of genetic material, gene expression and gene expression control, genetic variations and genetic engineering, as well as human genetics. In addition, Basic Genetics contains multiple choice questions covering each topic and their answers. These questions are absolutely essential for students' self- assessment. These different topics of basic genetics have also been illustrated by simple diagrams in full color.
The debate over human Genetic Engineering (GE) is about to go mainstream. Not as a one-day wonder about cloning or a theological disagreement about embryos, but as a major political issue, driven in part by a grassroots movement of opposition. Human Genetic Engineering is a highly readable and entertaining guide. It explains in accessible language for a popular audience the essential questions that will arise in the future debates: What is human GE? Will it work? What perspectives should we remember? Who is doing what, and why?
Psychiatric Genetics: A Primer for Clinical and Basic Scientists offers a straightforward introduction to the essentials of psychiatric genetics, covering basic epidemiology, recruitment for human studies, phenotyping strategies, formal genetic and molecular genetic studies, statistical genetics, bioinformatics and genomics, pharmacogenetics, the most relevant animal models, and biobanking. Each chapter begins with a list of "take home" points that summarizes content, followed by a brief overview of current knowledge and suggestions for further reading.
This timely book illustrates the value of bioinformatics, not simply as a set of tools but rather as a science increasingly essential to navigate and manage the host of information generated by genomics and the availability of completely sequenced genomes. Bioinformatics can be used at all stages of genetics research: to improve study design, to assist in candidate gene identification, to aid data interpretation and management and to shed light on the molecular pathology of disease-causing mutations. Written specifically for geneticists, this book explains the relevance of bioinformatics showing how it may be used to enhance genetic data mining and markedly improve genetic analysis.
This book covers basic concepts in population and quantitative genetics, including measuring selection on phenotypic traits. The emphasis is on material applicable to field studies of evolution focusing on ecologically important traits. Topics addressed are critical for training students in ecology, evolution, conservation biology, agriculture, forestry, and wildlife management. Many texts in this field are too complex and mathematical to allow the average beginning student to readily grasp the key concepts. A Primer of Ecological Genetics, in contrast, employs mathematics and statistics-fully explained, but at a less advanced level-as tools to improve understanding of biological principles. The main goal is to enable students to understand the concepts well enough that they can gain entry into the primary literature. Integration of the different chapters of the book shows students how diverse concepts relate to each other.
The DNA sequence that comprises the human genome--the genetic blueprint found in each of our cells--is undoubtedly the greatest code ever to be broken. Completed at the dawn of a new millennium, the feat electrified both the scientific community and the general public with its tantalizing promise of new and better treatments for countless diseases, including Alzheimer's, cancer, diabetes, and Parkinson's. Yet what is arguably the most important discovery of our time has also opened a Pandora's box of questions about who we are as humans and how the unique information stored in our genomes can and might be used, making it all the more important for everyone to understand the new science of genomics. In the CURIOSITY GUIDE TO THE HUMAN GENOME, Dr. John Quackenbush, a renowned scientist and professor, conducts a fascinating tour of the history and science behind the Human Genome Project and the technologies that are revolutionizing the practice of medicine today. With a clear and engaging narrative style, he demystifies the fundamental principles of genetics and molecular biology, including the astounding ways in which genes function, alone or together with other genes and the environment, to either sustain life or trigger disease. In addition, Dr. Quackenbush goes beyond medicine to examine how DNA-sequencing technology is changing how we think of ourselves as a species by providing new insights about our earliest ancestors and reconfirming our inextricable link to all life on earth. Finally, he explores the legal and ethical questions surrounding such controversial topics as stem cell research, prenatal testing, forensics, and cloning, making this volume of the Curiosity Guides series an indispensable resource for navigating our brave new genomic world.
The use of molecular methods to study genetic polymorphisms has made a familiarity with population genetics essential for any biologist whose work is at the population level. A Primer of Population Genetics, Third Edition provides a concise but comprehensive introduction to population genetics. The four chapters of the book address genetic variation, the causes of evolution, molecular population genetics, and the genetic architecture of complex traits. Chapter-end problems reinforce ideas and, while there are some equations, the emphasis is on explanation rather than derivation.
Geneticist Eugene Harris presents us with the complete and up-to-date account of the evolution of the human genome.