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In this comprehensive account of the history and treatment of beriberi, Kenneth Carpenter traces the decades of medical and chemical research that solved the puzzle posed by this mysterious disease. Caused by the lack of a minute quantity of the chemical thiamin, or vitamin B1 in the diet, beriberi is characterized by weakness and loss of feeling in the feet and legs, then swelling from fluid retention, and finally heart failure. Western doctors working in Asia after 1870 saw it as the major disease in native armed forces and prisons. It was at first attributed to miasms (poisonous vapors from damp soil) or to bacterial infections. In Java, chickens fed by chance on white rice lost the use of their legs. On brown rice, where the grain still contained its bran and germ, they remained healthy. Studies in Javanese prisons then showed beriberi also occurring where white (rather than brown) rice was the staple food. Birds were used to assay the potency of fractions extracted from rice bran and, after 20 years, highly active crystals were obtained. In another 10 years their structure was determined and "thiamin" was synthesized. Beriberi is a story of contested knowledge and erratic scientific pathways. It offers a fascinating chronicle of the development of scientific thought, a history that encompasses public health, science, diet, trade, expanding empires, war, and technology. From the preface: This is a medical detective story: beginning with the investigation of a disease that has killed or crippled at least a million people, and then following up clues that ranged much wider. One outcome was the production of a synthetic chemical that we now, nearly all of us, consume in small quantities each day in our food. The detectives had a variety of professions and spoke different languages. Their work ranged from studying the health of laborers in a primitive jungle to the painstaking dissection of individual grains of rice under a microscope. The integrated story of their struggles and successes, culled from old volumes in scattered libraries, forms the subject of this book.
A fascinating account of poultices, pills, and prescriptions over the centuries and how they’ve been developed and delivered. This lively account follows the development of medicines from traces of herbs found with the remains of Neanderthal man, to prescriptions written on clay tablets from Mesopotamia in the third millennium BC, to pure drugs extracted from plants in the nineteenth century, and to the latest biotechnology antibody products. In addition, it tells the stories behind historical figures in medicine, such as Christopher Wren, who gave the first intravenous injection in 1656, and William Brockedon, who invented the tablet in 1843, as well as recounting the changes in patterns of prescribing from simple dosage forms—such as liquid mixtures, pills, ointments, lotions, poultices, powders for treating wounds, inhalations, eye drops, enemas, pessaries, and suppositories mentioned in the Egyptian Ebers papyrus of 1550 BCE—to the complex tablets, injections, and inhalers in current use. A typical pharmacy now dispenses about as many prescriptions in a working day as a mid-nineteenth-century chemist did in a whole year. This history sheds light on the scientific progress made over centuries that led to the medical miracles of the modern world.
This groundbreaking volume captures and analyzes the exhilarating and at times disorienting experience when scientists, government officials, educators, and the general public in East Asia tried to come to terms with the introduction of Western biological and medical sciences to the region. The nexus of gender and health is a compelling theme, for this is an area in which private lives and personal characteristics encounter the interventions of public policies. The nine empirically based studies by scholars of history of medicine, sociology, anthropology, and STS (science, technology, and society), spanning Japan, Korea, China, Taiwan, and Hong Kong from the 1870s to the present, demonstrate just how tightly concerns with gender and health have been woven into the enterprise of modernization and nation-building throughout the long twentieth century. The concepts of “gender” and “health” have become so commonly used that one might overlook that they are actually complicated notions with vexed histories even in their native contexts. Transposing such terminologies into another historical or geographical dimension is fraught with problems, and what makes the East Asian cases in this volume particularly illuminating is that they present concepts of gender and health in motion. The studies show how individuals and societies made sense of modern scientific discourses on diseases, body, sex, and reproduction, redefining existing terms in the process and adopting novel ideas to face new challenges and demands. “Whether reviewing the comparative national histories of birth control, debating early cases of transsexual surgery, or highlighting the resurgence of ‘traditional’ Asian medical commodities, this volume provides accessible and productive studies on these intriguing topics in Asia. Scholars of modern East Asia and indeed anyone concerned with the analysis of gender and health in light of intersecting postcolonial studies will find the book rewarding.” —Rayna Rapp, New York University “A bold and important volume that explores the interweaving of gender, body, and modernity throughout East Asia. With vivid articles on sexuality, reproductive technologies, and sexual identities, the book opens multiple possibilities for how ‘Asia as method’ can shine new light on persistent theoretical questions from biopower to biocitizenship.” —Ruth Rogaski, Vanderbilt University