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The rationale of this study was to utilize the overproduction of mucin in cancerous cells as a drug targeting strategy to develop a safe and effective delivery system for taxol. Since the chemotherapeutic agents do not discriminate cancer cells and normal tissue, highly effective cancer treatment agents such as taxol cause major toxicity to normal tissue. This toxicity can be fatal if not prevented. The hypothesis for this project was a mucoadhesive in situ gel delivery system containing paclitaxel can be targeted to the cancerous cells where MUCl gene is overexpressed as compared to normal cells and substantially reduce its toxicity to normal cells. The primary objective of this investigation is to develop a sustained release novel in situ gel delivery system for the targeted local delivery of taxol. The delivery system was designed so that when injected close to the site of tumor, at the biological pH (7.4), the ionic polymer used in the delivery system would deprotonate and turn into an instant gel at the site of injection. This will provide a sustained release of paclitaxel (PIX) from the gel at and around the site of cancer while the systemic drug concentration will be negligible. The specific aims of this study are: 1) formulation, and physicochemical characterization of the in situ gel delivery system, and 2) evaluation of the effectiveness of the targeted local in situ gel delivery system verses the systemic delivery and determination of the local tissue and organ toxicity of the delivery system.
Novel drug delivery system has always been an component of formulation research curriculum this book 'Thermosensitive In-Situ Hydrogel and Nanosuspensions Techniques - Smart Sustained Release Injectable Formulations' for pharmacy students and researchers help to understand the concept of In-Situ gel formulation and Nanosuspension formulation with their evaluation to understand about polymer profile studies and polymer properties improvement by chemical means.
This book will describe current research on drug delivery systems that encompass four broad categories, namely: routes of delivery, delivery vehicles, payload, and targeting strategies. Where appropriate delivery vehicles and relevant release of specific agents in any of these categories in clinical application will be discussed. All chapters will highlight the translational aspects of the various technologies discussed and will provide insights into the advantages of such delivery systems over current ones in clinical or research use. Each technology reviewed in this book will have significant potential to improve patients' lives by enhancing the therapeutic efficacy of drugs. This book: Discusses the various factors that mitigate effective oral insulin delivery and the current status of research efforts to overcome these barriers along with recent clinical projections Examines the advantages and disadvantages of each drug delivery system Examines the standard method of accomplishing controlled drug release through the incorporation of the drugs within polymeric biomaterials such as capsules and microcapsules as well as other vehicles such as liposomes Discusses various controlled drug delivery systems, including sustained release delivery systems and pulse or delayed release, e.g. to target different regions of the gastrointestinal tract. In view of these wide-ranging technological areas, and the up-to-date discussions of opportunities and challenges associated with these applications, the book should provide readers from technology, materials science, pharmacology and clinical disciplines with very valuable information.
Chitosan in Drug Delivery provides thorough insights into chitosan chemistry, collection, chemical modifications, characterization and applications in the pharmaceutical industry and healthcare fields. The book explores molecular weight, degree of deacetylation and molecular geometry, emphasizing recent advances in the field as written by academic, industry and regulatory scientists. It will be a useful resource for pharmaceutical scientists, including industrial pharmacists, analytical scientists, postgraduate students, health care professionals and regulatory scientists actively involved in pharmaceutical product and process development in natural polymers containing drug delivery. Provides methodologies for the design, development and selection of chitosan in drug delivery for particular therapeutic applications Includes illustrations demonstrating the mechanism of biological interaction of chitosan Discusses the regulatory aspects and demonstrates the clinical efficacy of chitosan
This book examines the commercial role of various microbial polysaccharides and recent advances in their production. Offering an overview of the physiological role, biosynthetic pathways and regulatory mechanisms, it also explores the current challenges regarding bioprocessing for the production of polysaccharides.
Emphasizing four major classes of polymers for drug delivery-water-soluble polymers, hydrogels, biodegradable polymers, and polymer assemblies-this reference surveys efforts to adapt, modify, and tailor polymers for challenging molecules such as poorly water-soluble compounds, peptides/proteins, and plasmid DNA.
This book is focused on marine based biomedical carriers for delivery of therapeutics. Marine biomaterials and bio-based carriers show wide applications in pharmaceutical as well as biomedical fields for delivery of small and large molecules. Biomaterial-based composites, scaffolds or matrix systems are promising systems for controlled and prolonged release of drug in target site and control the premature release of drugs or bioactive compounds. This book discusses the targeted delivery of drugs and therapeutic applications. It also describes the use of marine biopolymers in cancer therapy. Different chapters describe the tissue engineering techniques to develop these carriers. The marine biomaterial-based systems are widely used for tissue engineering, and biomedical imaging. This book is meant for industry experts, students and researchers in the area of pharmaceutical sciences, biomedical engineering and material science and pharmacology.
Drug Targeting and Stimuli Sensitive Drug Delivery Systems covers recent advances in the area of stimuli sensitive drug delivery systems, providing an up-to-date overview of the physical, chemical, biological and multistimuli-responsive nanosystems. In addition, the book presents an analysis of clinical status for different types of nanoplatforms. Written by an internationally diverse group of researchers, it is an important reference resource for both biomaterials scientists and those working in the pharmaceutical industry who are looking to help create more effective drug delivery systems. Shows how the use of nanomaterials can help target a drug to specific tissues and cells Explores the development of stimuli-responsive drug delivery systems Includes case studies to showcase how stimuli responsive nanosystems are used in a variety of therapies, including camptothecin delivery, diabetes and cancer therapy