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One of the main applications of statistical smoothing techniques is nonparametric regression. For the last 15 years there has been a strong theoretical interest in the development of such techniques. Related algorithmic concepts have been a main concern in computational statistics. Smoothing techniques in regression as well as other statistical methods are increasingly applied in biosciences and economics. But they are also relevant for medical and psychological research. Introduced are new developments in scatterplot smoothing and applications in statistical modelling. The treatment of the topics is on an intermediate level avoiding too much technicalities. Computational and applied aspects are considered throughout. Of particular interest to readers is the discussion of recent local fitting techniques.
This volume constitutes the Proceedings of the joint meeting of GLIM89 and the 4th International Workshop on statistical Modelling, held in Trento, Italy, from 17 to 21 July 1989. The meeting aimed to bring together researchers interested in the development and application of generalized linear modelling in GLIM and those interested in statistical modelling in its widest sense. This joint meeting built upon the success of previous workshops held in Innsbruck, perugia and Vienna, and upon the two previous GLIM conferences , GLIM82 and GLIM85. The Proceedings of the latter two being available as numbers 14 and 32 in the springer Verlag series of Lecture Notes in Statistics). Much statistical modelling is carried out using GLIM, as is apparent from many of the papers in these Proceedings; however, the Programme Committee were also keen on encouraging papers which discussed more general modelling techniques. Thus about a third of the papers in this volume are outside the GLIM framework. The Programme Committee specifically requested non-theoretical papers in addition to considering theoretical contributions. Thus there are papers in a wide range of practical areas, such as radio spectral occupancy, comparison of birthweights, intervals between births, accidents of railway workers, genetics, demography, medical trials, the social sciences and insurance. A wide range of theoretical developments are discussed, for example, overdispersion, non-exponential family modelling, novel approaches to analysing contingency tables, random effects models, Kalman Filtering, model checking and extensions of Wedderburn's theoretical underpinning of GLMs.
The volume contains the proceedings of the 7th Workshop on Model-Oriented Design and Analysis which has had the purpose of bringing together leading researchers in Eastern and Western Europe for an in-depth discussion of the optimal design of experiments. The papers are representative of the latest developments concerning non-linear models, computational algorithms and important applications, especially to medical statistics.
Development in methodology on longitudinal data is fast. Currently, there are a lack of intermediate /advanced level textbooks which introduce students and practicing statisticians to the updated methods on correlated data inference. This book will present a discussion of the modern approaches to inference, including the links between the theories of estimators and various types of efficient statistical models including likelihood-based approaches. The theory will be supported with practical examples of R-codes and R-packages applied to interesting case-studies from a number of different areas. Key Features: •Includes the most up-to-date methods •Use simple examples to demonstrate complex methods •Uses real data from a number of areas •Examples utilize R code
Development in methodology on longitudinal data is fast. Currently, there are a lack of intermediate /advanced level textbooks which introduce students and practicing statisticians to the updated methods on correlated data inference. This book will present a discussion of the modern approaches to inference, including the links between the theories of estimators and various types of efficient statistical models including likelihood-based approaches. The theory will be supported with practical examples of R-codes and R-packages applied to interesting case-studies from a number of different areas. Key Features: •Includes the most up-to-date methods •Use simple examples to demonstrate complex methods •Uses real data from a number of areas •Examples utilize R code
Nonlinear measurement data arise in a wide variety of biological and biomedical applications, such as longitudinal clinical trials, studies of drug kinetics and growth, and the analysis of assay and laboratory data. Nonlinear Models for Repeated Measurement Data provides the first unified development of methods and models for data of this type, with a detailed treatment of inference for the nonlinear mixed effects and its extensions. A particular strength of the book is the inclusion of several detailed case studies from the areas of population pharmacokinetics and pharmacodynamics, immunoassay and bioassay development and the analysis of growth curves.
This book takes the standard methods as the starting point, and then describes a wide range of relatively new approaches and procedures designed to deal with more complicated data and experiments - including much recent research in the area. Throughout mention is given to the computing requirements - facilities available in large computing packages like BMDP, SAS and SPSS are also described.