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Middle ear infections or otitis media that cause inflammation of tympanic membrane and fluid buildup in the middle ear cavity accounts for 2-3 million hospital visits every year [34]. As per an epidemiological study conducted from 2006 - 2016 on 685 children, between the ages of 1-3 years, roughly 60% had at least one hospital visit due to ear infections [3]. Despite the high incidence, the diagnosis of otitis media is only 50% accurate (a coin toss) due to the subjective nature of diagnosis as the physicians look at the ear drum and detect the fluid behind the ear drum. To detect the fluid with high sensitivity and accurately diagnose middle ear infection, we propose a multispectral visible - nIR otoscope that operates in the range of 600 nm - 1050 nm. We have performed experiments to demonstrate the proof of concept of our device on phantoms that includes, 3D printed middle ear structure, tympanic membrane made of silicone, and orange juice as ear fluid all of which mimics the properties of human ear. The multispectral otoscope showed highest contrast between ossicles and fluid at 1000 nm which shows low attenuation of fluid and tympanic membrane at NIR wavelengths. The system is calibrated against a diffuse reflection surface to account for variations in source and detector. Our experiments showed that empty phantoms yielded almost equal contrast across the entire visible- NIR wavelength. Once the fluid is filled, the contrast increased by 30 ± 10 % in the visible wavelength (600 nm - 750 nm) and 120 ± 20 % in nIR wavelength (900 nm - 1000 nm). This 80% - 100% difference in contrast between visible and NIR wavelength is used to detect and highlight the areas of the middle ear filled with fluid.
Sensors for Health Monitoring discusses the characteristics of U-Healthcare systems in different domains, providing a foundation for working professionals and undergraduate and postgraduate students. The book provides information and advice on how to choose the best sensors for a U-Healthcare system, advises and guides readers on how to overcome challenges relating to data acquisition and signal processing, and presents comprehensive coverage of up-to-date requirements in hardware, communication and calculation for next-generation uHealth systems. It then compares new technological and technical trends and discusses how they address expected u-Health requirements. In addition, detailed information on system operations is presented and challenges in ubiquitous computing are highlighted. The book not only helps beginners with a holistic approach toward understanding u-Health systems, but also presents researchers with the technological trends and design challenges they may face when designing such systems. - Presents an outstanding update on the use of U-Health data analysis and management tools in different applications, highlighting sensor systems - Highlights Internet of Things enabled U-Healthcare - Covers different data transmission techniques, applications and challenges with extensive case studies for U-Healthcare systems
This book provides a thorough overview of the ongoing evolution in the application of artificial intelligence (AI) within healthcare and radiology, enabling readers to gain a deeper insight into the technological background of AI and the impacts of new and emerging technologies on medical imaging. After an introduction on game changers in radiology, such as deep learning technology, the technological evolution of AI in computing science and medical image computing is described, with explanation of basic principles and the types and subtypes of AI. Subsequent sections address the use of imaging biomarkers, the development and validation of AI applications, and various aspects and issues relating to the growing role of big data in radiology. Diverse real-life clinical applications of AI are then outlined for different body parts, demonstrating their ability to add value to daily radiology practices. The concluding section focuses on the impact of AI on radiology and the implications for radiologists, for example with respect to training. Written by radiologists and IT professionals, the book will be of high value for radiologists, medical/clinical physicists, IT specialists, and imaging informatics professionals.
This comprehensive multidisciplinary book examines all aspects of cancers of the mouth and oropharynx with the aim of equipping advanced students and practitioners in the early stages of specialist training with an up-to-date guide and reference. A multinational team of authors – all experts in the field of oral oncology – provide illuminating contributions on the full range of relevant topics: epidemiology, risk factors, clinical features, staging and prognostic factors, pathology, diagnostic techniques, disease prevention, surgery, radiotherapy, and chemotherapy. Molecular biology, molecular targeted therapies for advanced cases, and future diagnostic and prognostic applications of new technologies also receive careful attention. In providing a wealth of essential information and guidance in a practical format, the book will be a superb asset for senior graduate students in dentistry and specialist trainees in head and neck oncology. It will also be of high value for the many physicians, surgeons, pathologists, dentists, and specialists involved in the prevention, diagnosis, and management of squamous cell carcinomas of the oral cavity and oropharynx.
This manual is a dual-Service US Army and US Marine Corps publication introducing new terms and definitions and updating existing definitions as reflected in the latest editions of Army field manuals and Marine Corps doctrinal, warfighting, and reference publications. It complies with DOD Military Standard 2525. When communicating instructions to subordinate units, commanders and staffs from company through corps should use this manual as a dictionary of operational terms and military graphics.
This text serves as a very useful clinical guide and realistic approach to the clinical management of melanoma. Primary care physicians, specialists from varying areas of medical practice and numerous other healthcare providers will find this text to be quite useful as a standard daily reference and use in the office setting. It provides a clear and concise source of information in order to make real-life, evidence-based decisions for all aspects of management for cutaneous melanoma. This book also provides the latest breakthroughs in melanoma research, ranging from recent discoveries in genomics and epigenetics, to newly identified genes that have been selectively targeted for the development of a personalized approach to treatment. All chapters are written by specialists and true experts within their respective fields, incorporating the latest scientific, clinical and evidence-based medicine for melanoma (and non-melanoma skin cancers). This up-to-date information can be easily applied and translated to the clinical setting for the melanoma patient.
This new handbook covers the world of biophotonics not only geographically -- with the editors coming from different continents -- but also in terms of content, since the authors come from the whole spectrum of biophotonic basic and applied research. Designed to set the standard for the scientific community, these three volumes break new ground by providing readers with the physics basics as well as the biological and medical background, together with detailed reports on recent technical advances. The Handbook also adopts an application-related approach, starting with the application and then citing the various tools to solve the scientific task, making it of particular value to medical doctors. Divided into several sections, the first part offers introductory chapters on the different fields of research, with subsequent parts focusing on the applications and techniques in various fields of industry and research. The result is a handy source for scientists seeking the basics in a condensed form, and equally a reference for quickly gathering the knowledge from neighboring disciplines. Absolutely invaluable for biophotonic scientists in their daily work.
This book constitutes the refereed proceedings of the 5th International Symposium on Advances in Signal Processing and Intelligent Recognition Systems, SIRS 2019, held in Trivandrum, India, in December 2019. The 19 revised full papers and 8 revised short papers presented were carefully reviewed and selected from 63 submissions. The papers cover wide research fields including information retrieval, human-computer interaction (HCI), information extraction, speech recognition.
This detailed volume for the first time explores techniques and protocols involving quantitative imaging flow cytometry (IFC), which has revolutionized our ability to analyze cells, cellular clusters, and populations in a remarkable fashion. Beginning with an introduction to technology, the book continues with sections addressing protocols for studies on the cell nucleus, nucleic acids, and FISH techniques using an IFC instrument, immune response analysis and drug screening, IFC protocols for apoptosis and cell death analysis, as well as morphological analysis and the identification of rare cells. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Imaging Flow Cytometry: Methods and Protocols will be a critical source for all laboratories seeking to implement IFC in their research studies.
This classic text on multiple regression is noted for its nonmathematical, applied, and data-analytic approach. Readers profit from its verbal-conceptual exposition and frequent use of examples. The applied emphasis provides clear illustrations of the principles and provides worked examples of the types of applications that are possible. Researchers learn how to specify regression models that directly address their research questions. An overview of the fundamental ideas of multiple regression and a review of bivariate correlation and regression and other elementary statistical concepts provide a strong foundation for understanding the rest of the text. The third edition features an increased emphasis on graphics and the use of confidence intervals and effect size measures, and an accompanying CD with data for most of the numerical examples along with the computer code for SPSS, SAS, and SYSTAT. Applied Multiple Regression serves as both a textbook for graduate students and as a reference tool for researchers in psychology, education, health sciences, communications, business, sociology, political science, anthropology, and economics. An introductory knowledge of statistics is required. Self-standing chapters minimize the need for researchers to refer to previous chapters.