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This book provides detailed information on therapeutic radiopharmaceuticals and discusses emerging technologies which have potential for broad clinical implementation. Recent advances in molecular biology, radiopharmaceutical chemistry and radioisotope production have stimulated a new era for the use of radiopharmaceuticals for targeted radionuclide therapy (TRT). Emerging clinical trials include use of peptides and monoclonal antibodies radiolabeled with therapeutic radionuclides for cancer therapy. In addition, small molecules are used for the treatment of chronic diseases such as metastatic bone pain palliation and radiation synovectomy of inflammatory joints. In the interventional arena, therapy of primary and metastatic liver cancer and arterial restenosis following angioplasty of both the coronary and peripheral arteries are being explored. Reactor and accelerator production of therapeutic radioisotopes is also integrated into these discussions. The development and use of radiopharmaceutical targeting characteristics required for treatment of specific disease processes and how these are implemented for radiopharmaceutical design strategies are also described. Radiopharmaceuticals for Therapy will benefit audiences in nuclear medicine and radionuclide therapy and will thus prove an invaluable source of up-to-date information for students, radiopharmaceutical scientists and professionals working in the radiopharmacy and nuclear medicine specialties.
This book discusses important fundamentals of radiation safety with specific details on dose units, calculations, measuring, and biological effects of ionizing radiation. The author covers different exposure situations and their requirements, and relevant legislation and regulations governing radiation safety. The book also examines radioactive waste management, the transport of radioactive materials, emergency planning and preparedness and various examples of radiation protection programs for industrial, medical, and academic applications.
This book on Marine Radioactivity sets out to cover most of the aspects of marine radioactivity which have been the focus of scientific study in recent decades. The authors and their reviews divide into topic areas which have defined the field over its history. They cover the suite of natural radioisotopes which have been present in the oceans since their formation and quantitatively dominate the inventory of radioactivity in the oceans. Also addressed are the suite of artificial radionuclides introduced to the oceans as a consequence of the use of the atom for development of nuclear energy, nuclear weapons and various applications of nuclear science. The major source of these continues to derive from the global fallout of atmospheric tests of nuclear weapons in the 1950s and 1960s but also includes both planned and accidental releases of radioactivity from both civilian and military nuclear technology. The other division of the major study direction depends on whether the objective is to use the radionuclides as powerful tools to study oceanic processes, to describe and understand the ocean distribution of the various natural or artificial radionuclides or to assess the different radionuclides' impact on and pathways to man or marine organisms. The oceans cover 70% of the Earth's surface and thus contains a corresponding large share of the Earth's radioactivity. Marine Radioactivity covers topics of recent scientific study in this young field. It examines both natural radioactivity (radioactivity naturally present in oceans since their formation) and artificial radioactivity (radioactivity introduced by man and use of atomic and nuclear energy) with regard to possible effects on the global environment.