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Ecotoxiclogical risk from multiple stressors covers any situation where org- isms are exposed to a combination of environmental stressors. These include physical and chemical pollutants as well as other stressors such as parasites and environmental impact (e. g. , climate change or habitat loss). The combi- tion of stressors can result in increased risk to organisms (either additive or synergistic effects) or decreased effects (protective or antagonistic effects). The multiple stressor challenge is an international, multi-disciplinary problem requiring an international, multi-disciplinary approach. The c- rent approach to multiple stressors is to examine one stressor at a time and assume additivity. Little work has been done on combinations of stressors such that potential interactions can be determined. The problem is very complex. Multiple stressors pose a whole spectrum of challenges that range from basic science to regulation, policy and gove- ance. The challenges raise fundamental questions about our understanding of the basic biological response to stressors, as well as the implications of those uncertainties in environmental risk assessment and management. In addition to the great breadth, there is also great depth in the research ch- lenges, largely due to the complexity of the issues. From a basic science point of view, many of the mechanisms and processes under investigation are at the cutting edge of science — involving new paradigms such as genomic ins- bility and bystander effects.
This extraordinary book tells of the creation of the world-class checkers computer program, Chinook. From its beginnings in 1988, Chinook became a worthy opponent to the world champion and by 1992 had defeated all the worlds top human players. In his fascinating account, Jonathan Schaeffer, the originator and leader of the Chinook team, provides an engrossing story of failures and successes. He describes the human story behind Chinook and his own feelings in his continuous effort to improve the programs performance. We follow the development of Chinook from an innocent question asked over lunch, through to the final match against the then world champion, Marion Tinsley. As the story unfolds, readers are introduced to the rules of checkers and the basics of computer game programs, as well as to the key figures in the story. The culmination of this new edition expounds upon checker finally perfected and solved by Chinook ten years after the story was originally told.
Civil infrastructure systems are generally the most expensive assets in any country, and these systems are deteriorating at an alarming rate. In addition, these systems have a long service life in comparison to most other commercial products. As well, the introduction of intelligent materials and innovative design approaches in these systems is painfully slow due to heavy relianceon traditional construction and maintenance practices, and the conservative nature of design codes. Feedback on the "state of the health" of constructed systems is practically nonexistent. In the quest for lighter, stronger and corrosion-resistant structures, the replacement of ferrous materials by high-strength fibrous ones is being actively pursued in several countries around the world, both with respect to the design of new structures as well as for the rehabilitation and strengthening of existing ones. In North America, active research in the design of new highway bridges is focused on a number of specialty areas, including the replacement of steel reinforcing bars in concrete deck slabs by randomly distributed low-modulus fibers, and the replacement of steel prestressing cables for concrete components by tendons comprising super-strong fibers. Research is also being conducted on using FRPs to repair and strengthen existing structures.
This volume provides an in-depth introduction to 3D printing and biofabrication and covers the recent advances in additive manufacturing for tissue engineering. The book is divided into two parts, the first part on 3D printing discusses conventional approaches in additive manufacturing aimed at fabrication of structures, which are seeded with cells in a subsequent step. The second part on biofabrication presents processes which integrate living cells into the fabrication process.
Since the first papers by E. N. Leith and J. Upatnieks on the subject of holography appeared in 1961, there has been a virtual explosion of research activity in the field. More than SOO papers and articles on holo graphy have appeared in the last ten years. Many applications of holo graphy have been proposed, and some of these are beginning to enter the realm of usefulness. One of the applications that appears to hold great promise is acoustic imaging by means of holography. The first papers on this subject appeared in 1966. but already research activity in the field is burgeoning. Tbree symposia whoUy devoted to acoustical holography have been held and tbe papers published in book form. The purpose of this book is to bring together the results of research in acoustical holography, some of it as yet unpublished, under one cover so that workers in holography, nondestructive testing, medical imaging, underwater imaging, and seismic exploration can decide whether this new technique can be useful to them.