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This is the first edited volume on response surface methodology (RSM). It contains 17 chapters written by leading experts in the field and covers a wide variety of topics ranging from areas in classical RSM to more recent modeling approaches within the framework of RSM, including the use of generalized linear models. Topics covering particular aspects of robust parameter design, response surface optimization, mixture experiments, and a variety of new graphical approaches in RSM are also included. The main purpose of this volume is to provide an overview of the key ideas that have shaped RSM, and to bring attention to recent research directions and developments in RSM, which can have many useful applications in a variety of fields. The volume will be very helpful to researchers as well as practitioners interested in RSM''s theory and potential applications. It will be particularly useful to individuals who have used RSM methods in the past, but have not kept up with its recent developments, both in theory and applications. Sample Chapter(s). Chapter 1: Two-Level Factorial and Fractional Factorial Designs in Blocks of Size Two. Part 2 (560 KB). Contents: Two-Level Factorial and Fractional Factorial Designs in Blocks of Size Two. Part 2 (Y J Yang & N R Draper); Response Surface Experiments on Processes with High Variation (S G Gilmour & L A Trinca); Random Run Order, Randomization and Inadvertent Split-Plots in Response Surface Experiments (J Ganju & J M Lucas); Statistical Inference for Response Surface Optima (D K J Lin & J J Peterson); A Search Method for the Exploration of New Regions in Robust Parameter Design (G Mer-Quesada & E del Castillo); Response Surface Approaches to Robust Parameter Design (T J Robinson & S S Wulff); Response Surface Methods and Their Application in the Treatment of Cancer with Drug Combinations: Some Reflections (K S Dawson et al.); Generalized Linear Models and Response Transformation (A C Atkinson); GLM Designs: The Dependence on Unknown Parameters Dilemma (A I Khuri & S Mukhopadhyay); Design for a Trinomial Response to Dose (S K Fan & K Chaloner); Evaluating the Performance of Non-Standard Designs: The San Cristobal Design (L M Haines); 50 Years of Mixture Experiment Research: 1955OCo2004 (G F Piepel); Graphical Methods for Comparing Response Surface Designs for Experiments with Mixture Components (H B Goldfarb & D C Montgomery); Graphical Methods for Assessing the Prediction Capability of Response Surface Designs (J J Borkowski); Using Fraction of Design Space Plots for Informative Comparisons between Designs (C M Anderson-Cook & A Ozol-Godfrey); Concepts of Slope-Rotatability for Second Order Response Surface Designs (S H Park); Design of Experiments for Estimating Differences between Responses and Slopes of the Response (S Huda). Readership: Researchers in academia and industry interested in response surface methodology and its applications; engineers interested in improving quality and productivity in industry."
Gender-Structured Population Modeling: Mathematical Methods, Numerics, and Simulations gives a unified presentation of and mathematical framework for modeling population growth by couple formation.
This very provocative book takes the reader on a “think-out-of-the-box” journey through the development of a treatment regimen for multiple myeloma called “dtZ”. It is a firsthand account of how more than 50 patients with myeloma were given a non-toxic, precisely-targeted, anti-cancer treatment that was specifically adapted to their individual cancers. These Individualized Anti-Cancer Targeted Therapies (smart bombs) have produced amongst the best responses as well as survival rates for myeloma. Accordingly, the author argues that some patients might even have been “cured” of their cancers.The concepts and logic behind “dtZ” are carefully presented in simple language so that both doctors and patients can easily understand them. Numerous tables and figures are provided, together with clear and simple explanations. This book is a valuable resource for all patients with myeloma who want to get the most out of their treatment by individualizing treatment to suit their needs, particularly for patients who have just been diagnosed with myeloma and who are taking that very important first step in their treatment. It is also a useful guide for doctors, nurses and researchers who treat and/or study myeloma.
Continuing the authors’ multivolume project, this text considers the theory of distributions from an applied perspective, demonstrating how effective a combination of analytic and probabilistic methods can be for solving problems in the physical and engineering sciences. Volume 1 covered foundational topics such as distributional and fractional calculus, the integral transform, and wavelets, and Volume 2 explored linear and nonlinear dynamics in continuous media. With this volume, the scope is extended to the use of distributional tools in the theory of generalized stochastic processes and fields, and in anomalous fractional random dynamics. Chapters cover topics such as probability distributions; generalized stochastic processes, Brownian motion, and the white noise; stochastic differential equations and generalized random fields; Burgers turbulence and passive tracer transport in Burgers flows; and linear, nonlinear, and multiscale anomalous fractional dynamics in continuous media. The needs of the applied-sciences audience are addressed by a careful and rich selection of examples arising in real-life industrial and scientific labs and a thorough discussion of their physical significance. Numerous illustrations generate a better understanding of the core concepts discussed in the text, and a large number of exercises at the end of each chapter expand on these concepts. Distributions in the Physical and Engineering Sciences is intended to fill a gap in the typical undergraduate engineering/physical sciences curricula, and as such it will be a valuable resource for researchers and graduate students working in these areas. The only prerequisites are a three-four semester calculus sequence (including ordinary differential equations, Fourier series, complex variables, and linear algebra), and some probability theory, but basic definitions and facts are covered as needed. An appendix also provides background material concerning the Dirac-delta and other distributions.
At some time 30% of the world’s land mass was covered by glaciers leaving substantial deposits of glacial soils under major conurbations in Europe, North and South America, New Zealand, Europe and Russia. For instance, 60% of the UK has been affected, leaving significant glacial deposits under major conurbations where two thirds of the population live. Glacial soils are composite soils with significant variations in composition and properties and are recognised as challenging soils to deal with. Understanding the environment in which they were formed and how this affects their behaviour are critical because they do not always conform to classic theories of soil mechanics. This book is aimed at designers and contractors working in the construction and extractive industries to help them mitigate construction hazards on, with or in glacial deposits. These soils increase risks to critical infrastructure which, in the UK includes the majority of the road and rail network, coastal defences such as the fastest eroding coastline in Europe and most of the water supply reservoirs. It brings together many years of experience of research into the behaviour of glacial deposits drawing upon published and unpublished case studies from industry. It draws on recent developments in understanding of the geological processes and the impact they have upon the engineering properties, construction processes and performance of geotechnical structures. Unlike other books on glaciation it brings together all the relevant disciplines in earth sciences and engineering to make it directly relevant to the construction industry.
The Loma Prieta earthquake struck the San Francisco area on October 17, 1989, causing 63 deaths and $10 billion worth of damage. This book reviews existing research on the Loma Prieta quake and draws from it practical lessons that could be applied to other earthquake-prone areas of the country. The volume contains seven keynote papers presented at a symposium on the earthquake and includes an overview written by the committee offering recommendations to improve seismic safety and earthquake awareness in parts of the country susceptible to earthquakes.